Epitalon
Epitalon is an AEDG tetrapeptide studied for telomerase activation, circadian regulation, and cellular longevity.
- Cellular longevity & anti-aging
- Telomerase activation research
- Restored circadian & melatonin rhythms
- Antioxidant cellular protection
- Balanced pineal-axis support
Epitalon is an AEDG tetrapeptide studied for telomerase activation, circadian regulation, and cellular longevity.
- Cellular longevity & anti-aging
- Telomerase activation research
- Restored circadian & melatonin rhythms
- Antioxidant cellular protection
- Balanced pineal-axis support
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If a batch tests below its documented purity, full refund on your order + testing fees.
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If a batch tests below its documented purity, full refund on your order + testing fees.
PubChem chemical profile not available for this compound.
View on PubChemEpitalon — Research Reference
A synthetic AEDG tetrapeptide derived from pineal-gland peptide research, studied for telomerase activation, circadian regulation, and cellular-longevity endpoints in animal-model and cell-culture systems.
What is Epitalon?
Epitalon (also spelled Epithalon) is a synthetic tetrapeptide with the amino-acid sequence Ala-Glu-Asp-Gly (AEDG), derived from research on the pineal-gland extract epithalamin conducted primarily at the Saint Petersburg Institute of Bioregulation and Gerontology. It is one of the most-cited peptides in the longevity and cellular-senescence research literature, with a large body of published rodent-model and human-cell-culture work documenting telomerase upregulation, extended replicative capacity of somatic cells, restoration of circadian melatonin rhythms in aged models, and modulation of the HPG (hypothalamic-pituitary-gonadal) axis. Noxa Labs supplies Epitalon as a third-party tested analytical reference material for in-vitro research only. Note: this compound is supplied strictly as an analytical reference material for in vitro research by qualified professionals. It is not a pharmaceutical product, supplement, or substance for human or animal use.
Mechanism in research literature
The most-cited mechanistic finding is telomerase activation. Cultured human somatic-cell studies published in the early 2000s documented Epitalon inducing measurable telomerase activity and extending replicative lifespan of fibroblasts beyond the classical Hayflick limit — an effect notable because most somatic cells lack meaningful telomerase expression in adulthood. The AEDG sequence is described in the literature as binding chromatin regions associated with telomerase-related gene promoters, upregulating hTERT expression in exposed cells. Beyond telomere biology, animal-model studies describe restoration of the day-night melatonin secretion pattern in aged animals, normalisation of cortisol rhythms, and modulation of gonadotropin release consistent with a pineal-axis mechanism. Additional research documents antioxidant activity — reductions in lipid peroxidation markers — in oxidatively-challenged cell cultures. Reviews across the gerontology and pineal-peptide literature summarise Epitalon as a chromatin-active tetrapeptide whose signature research finding is telomere-related, complemented by circadian-axis effects.
Documented research applications
Documented research contexts include telomerase and telomere-length assays in human somatic-cell culture; cellular-senescence and replicative-lifespan research; circadian-rhythm and melatonin-secretion studies in aged rodent models; HPG-axis and gonadotropin research; antioxidant and oxidative-stress assays; and chromatin-binding structure-activity studies of short peptides. Epitalon is a standard reference tool in the pineal-peptide and gerontology research families.
Reconstitution
Epitalon is supplied lyophilised. Reconstitute with bacteriostatic water for injection (BAC water) to a working concentration appropriate to your assay. A 10 mg vial reconstituted with 1 mL BAC water yields a 10 mg/mL working stock. Direct diluent against the vial wall and swirl gently until fully dissolved.
Storage & stability
Lyophilised Epitalon is stable at room temperature for short transit periods. For long-term storage hold at 2–8 °C protected from light. Once reconstituted, store at 2–8 °C and use within 3–4 weeks per the batch COA.
Availability in the Philippines
Noxa Labs ships Epitalon from Metro Manila cold storage. Same-day NCR dispatch on Mon–Fri orders placed before 2 PM PHT. Nationwide arrival in 2–3 business days via Grab Express, Lalamove, LBC, or JRS Express.
Frequently asked questions
All Noxa Labs products are supplied strictly as analytical reference materials for qualified in vitro research. They are not pharmaceutical products, food supplements, or substances for human or animal consumption.
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